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The basic requirements are below:
Your report should have the following major sections at minimum:
Introduction and Rationale
Include discussion on tissue engineering approaches and/or device(s)
Clearly state the focus of this report
Discuss how findings, from a tissue engineering perspective, will advance medical science.
Comment on how biology and/or physiology are important to the development of the approach/application.
Summarize how the research results found in the literature articles show the potential of the solution and the impact on patient health.
Describe the critical experimental methods used in the literature articles you cite that are most relevant to understanding this thesis
Describe the critical experimental models used for investigation in the literature articles you cite (in vitro, animal, human, etc.)
Identify all the components/parts of the engineered solution and how they could be produced/obtained
Important Protein Player
Choose a protein that plays an important role in the function of your device/concept
Explain what role the protein plays (ligand, receptor, etc.) and its general structure (alpha helix, beta sheet, multiple units, etc.)
Explain how the protein functions in its role
This protein can be an actual piece of the device, or it can be an endogenous protein that interacts with it.
One Key Signaling Pathway
Describe and diagram one key signaling pathway that is important to the functioning of your device/concept. It is acceptable to copy a diagram of the pathway from a book/drawing, as long as the diagram is cited.
While Sections 5-6 may involve the same protein, describe the protein in Section 5 and the pathway in Section 6.
Alternatively, you can describe a different signaling pathway here that does not involve the protein from Section 5.
The pathway may be something the device directly interacts with, or it may be a pathway involved in the growth/regeneration/repair/genesis of the tissue type that interacts with your device.
Important Cellular Interactions
Describe and diagram one key intercellular interaction that is important to the functioning of your device/concept. It is acceptable to copy a diagram of the interaction from a book/drawing, as long as the diagram is cited.
The interaction may relate to the Signaling Pathway in Section 6, or it may be an un-related separate interaction. If it is related, explain how the signaling pathway (which is intracellular) links up with the intercellular interaction.
The cellular interaction may be something the device directly interacts with, or it may be an interaction involved in the growth/regeneration/repair/genesis of the tissue type that interacts with your device.
Biocompatibility of the Device/Concept
Conclude with how the engineered solution will provide the intended function.
Include a discussion on the interactions of the Inflammatory and Immune systems. This could be a discussion on wound healing in general if that is the intent of the solution, or if the solution involves a surgical procedure that requires wound healing.
Clearly identify the limitations of the research conclusions in regards to biocompatibility and patient health.
Literature Search Keywords – Include all the keyword information from your literature search keyword assignment. Make sure it is updated and includes all new keywords used to revise/bolster your search. (If you changed nothing since your initial literature search, this is just a copy/paste of your literature search keywords. Be sure to update if you had corrections or additions.)
Screening Log – Include the screening log from your literature keyword search assignment. Make sure it is updated and includes ALL articles from your final search and their rejection reasons, if applicable.
Bibliography – Include all the articles you used in your report. It is not necessary to include articles in your bibliography that were rejected in your screening log.
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